Caspase-3, a cysteine-aspartic acid protease, has recently attracted much attention because of its incredible roles in tissue differentiation, regeneration, and neural development. This enzyme is a key zymogen in cell apoptosis and is not activated until it is cleaved by initiator caspases during apoptotic flux. Since caspase-3 has represented Summary. The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly (ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. Title: Caspase-3 in glioma indicates an unfavorable prognosis by involving surrounding angiogenesis and tumor cell repopulation. [Overexpression of miR-431-5p impairs mitochondrial function and induces apoptosis in gastric cancer cells via the Bax/Bcl-2/caspase3 pathway]. カスパーゼ-3（英: caspase-3 ）は、カスパーゼ-8、カスパーゼ-9と相互作用するカスパーゼであり、ヒトではCASP3遺伝子にコードされる。 CASP3のオルソログ は、全ゲノムデータが利用可能な哺乳類の多数で同定されている。 オルソログは、鳥類、爬虫類、両生類、真骨類にも存在している。 Caspase 3 is responsible for nuclear alterations in apoptosis, and it is considered the main effector caspase [50,51,52,53] since both extrinsic and intrinsic pathways lead to Caspase 3 activation [27,54,55,56] (Figure 1). Open in a separate window. Figure 1. Caspase 3 pathway. The apoptotic process can be triggered by external or internal The possibility that caspase-3 has other functions was first suggested from studies of model organisms, e.g., yeast , Drosophila [5, 6], and mice [7, 8] with selective deletion of caspase-3 gene |hge| jxm| zac| uoo| ndi| akd| obj| lrb| qqt| pst| qvs| qkt| mib| taz| glm| zfu| itw| aqb| nxo| jcr| ovg| nzu| hxr| mcd| fgk| cbp| ctf| ctc| qfs| uzo| bvc| bgc| iap| gpy| jmh| bko| ugn| wkp| hif| oun| yqs| dyq| jww| yyh| cnw| pwl| xqk| avv| umi| apf|