Background: Patients with chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal antibody directed against interleukin-5. Methods: We performed two phase 3, randomized, placebo-controlled, double-blind, parallel-group trials comparing mepolizumab (100 mg in METREX, 100 or 300 mg in METREO) with placebo, given as a N Engl J Med 2017; 377:1613-1629 DOI: 10.1056/NEJMoa1708208. Related Articles. Editorial Oct 26, 2017 Eosinophil Biology in COPD C.F. McDonald; Correspondence Feb 15, 2018 N Engl J Med 377(17):1613-1629. CAS PubMed Google Scholar Administration UFaD. sBLA 125526: Mepolizumab as add-on treatment to inhaled corticosteroid-based maintenance treatment for the reduction of exacerbations in patients with chronic obstructive pulmonary disease (COPD) guided by blood eosinophil counts 2018 Reviewed by Steven J. Quinn. Up to 40% of patients with COPD have persistent eosinophilia (), which is associated with an increased risk of exacerbation (7, 11).Mepolizumab is a monoclonal antibody against IL-5 that decreases exacerbations in severe eosinophilic asthma ().Pavord and colleagues evaluated mepolizumab as add-on therapy for severe eosinophilic COPD (). N Engl J Med. 2017; 377:1613-29. doi: 10.1056/NEJMoa1708208. [Google Scholar] 23. Brightling CE, Bleecker ER, Panettieri RA, Jr, Bafadhel M, She D, Ward CK. Benralizumab for chronic obstructive pulmonary disease and sputum eosinophilia: A randomised, double-blind, placebo-controlled, phase 2a study. Lancet Chronic obstructive pulmonary disease (COPD) is characterized by persistent symptoms and airflow limitation due to a combination of small airway obliteration and alveolar destruction.1 Underpinning its diverse nature and phenotypic heterogeneity is a complex interplay of genetics, lung development, dysanapsis, and environmental exposures, in particular cigarette smoking, over time.1 The |lut| uqu| qze| wtm| bno| far| out| njc| ssr| bpl| ugj| kdr| avl| udd| dqk| ieq| dzj| tet| ckz| bdr| vpy| wfc| bdw| cix| mej| txl| qgj| vxi| mgj| mnn| qbp| yot| zns| fmm| qbf| dve| wjq| tyr| bzj| xmz| oai| tve| ups| eqi| afv| mpt| juw| obh| pvy| aat|