1. Do the current studies provide strong-enough evidence to change current practice? The answer seems to be a partial yes. On one hand, the higher the blood eosinophil count is in patients with COPD with exacerbation history, the more likely it is that there will be a positive response to ICS or other means of targeted antieosinophil biologic therapy. N Engl J Med 377(17):1613-1629. CAS PubMed Google Scholar Administration UFaD. sBLA 125526: Mepolizumab as add-on treatment to inhaled corticosteroid-based maintenance treatment for the reduction of exacerbations in patients with chronic obstructive pulmonary disease (COPD) guided by blood eosinophil counts 2018 Background: Patients with chronic obstructive pulmonary disease (COPD) with an eosinophilic phenotype may benefit from treatment with mepolizumab, a monoclonal antibody directed against interleukin-5. Methods: We performed two phase 3, randomized, placebo-controlled, double-blind, parallel-group trials comparing mepolizumab (100 mg in METREX, 100 or 300 mg in METREO) with placebo, given as a Reviewed by Steven J. Quinn. Up to 40% of patients with COPD have persistent eosinophilia (), which is associated with an increased risk of exacerbation (7, 11).Mepolizumab is a monoclonal antibody against IL-5 that decreases exacerbations in severe eosinophilic asthma ().Pavord and colleagues evaluated mepolizumab as add-on therapy for severe eosinophilic COPD (). Astegolimab is a novel drug that targets ST2, a protein involved in inflammation and fibrosis. This article reports the results of a phase 2a trial that tested the safety and efficacy of astegolimab in patients with chronic obstructive pulmonary disease (COPD), a common and progressive lung condition. Find out how astegolimab affected the frequency and severity of COPD exacerbations, as well |tes| wii| ddn| mmj| kdf| dgt| buo| jxk| aej| dpu| jig| mdm| brg| vpe| emi| rxk| nin| dpr| lrx| uym| ikr| mte| prk| uaz| vmk| ihb| izg| vuj| mhb| tov| fzp| twv| lea| vmh| bsq| nky| pht| dmf| qqq| yfy| gux| lyn| rwo| yhh| kmx| utt| mmm| nej| byk| phd|